RRM1 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comRRM1 Polyclonal Antibody for Human(Homo sapiens)

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RRM1 (Gene name),

Ribonucleoside-diphosphate reductase large subunit (Protein name ), RIR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

RRM1(RR1);

Protein name:

Ribonucleoside-diphosphate reductase large subunit;

Alternative:

Ribonucleotide reductase large subunit;Ribonucleoside-diphosphate reductase subunit M1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B.

Function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

792

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

792:

TLNKEKLKDK | EKVSKEEEEK | ERNTAAMVCS | LENRDECLMC | GS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:6240

MIM:

180410

UniGene:

Hs.445705

String:

P23921

Pfam:

PF03477

SMR:

P23921

STRING:

9606.ENSP00000300738

Uniprot:

P23921

FOR

ELISA Kit for Human Ribonucleoside-diphosphate reductase large subunit

Cat.:

E0190h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Ribonucleoside-diphosphate reductase large subunit

Cat.:

E0190m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Ribonucleoside-diphosphate reductase large subunit

Cat.:

U0190m

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MSDS:

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Packing:

96T

CLIA Kit for Human Ribonucleoside-diphosphate reductase large subunit

Cat.:

U0190h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Ribonucleoside-diphosphate reductase large subunit

Cat.:

P0190Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ribonucleoside-diphosphate reductase large subunit

Cat.:

P0190Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Ribonucleoside-diphosphate reductase large subunit

Protein for Human Ribonucleoside-diphosphate reductase large subunit

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human M1 subunit of ribonucleotide reductase: cDNA sequence and expression in stimulated lymphocytes."
Parker N.J. , Begley C.G. , Fox R.M.
Nucleic Acids Res.19:3741-3741(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Bone marrow.
2.

"Sequence analysis of the large and small subunits of human ribonucleotide reductase."
Pavloff N. , Rivard D. , Masson S. , Shen S.-H. , Mes-Masson A.-M.
DNA Seq.2:227-234(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Mammary carcinoma.
3.

"A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region."
Bepler G. , O'Briant K.C. , Kim Y.-C. , Schreiber G. , Pitterle D.M.
Genomics55:164-175(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lymph.
5.

"Human R1 subunit of ribonucleotide reductase (RRM1): 5' flanking region of the gene."
Parker N.J. , Begley C.G. , Fox R.M.
Genomics19:91-96(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6
tissue: Placenta.
6.

"Human ribonucleotide reductase. Activation and inhibition by analogs of ATP."
Harrington J.A. , Spector T.
Biochem. Pharmacol.42:759-763(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
7.

"Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits."
Xue L. , Zhou B. , Liu X. , Qiu W. , Jin Z. , Yen Y.
Cancer Res.63:980-986(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RRM2B
8.

"Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits."
Qiu W. , Zhou B. , Darwish D. , Shao J. , Yen Y.
Biochem. Biophys. Res. Commun.340:428-434(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;SUBUNIT;ENZYME REGULATION
9.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-17 AND LYS-376;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes."
Arnaoutov A. , Dasso M.
Science345:1512-1515(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;MUTAGENESIS OF ASP-57;INTERACTION WITH AHCYL1
12.

"Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization."
Fairman J.W. , Wijerathna S.R. , Ahmad M.F. , Xu H. , Nakano R. , Jha S. , Prendergast J. , Welin R.M. , Flodin S. , Roos A. , Nordlund P. , Li Z. , Walz T. , Dealwis C.G.
Nat. Struct. Mol. Biol.18:316-322(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 75-742 IN COMPLEX WITH ALLOSTERIC EFFECTOR ATP AND MAGNESIUM IONS

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